Cotinine is the first-stage metabolite of a toxic alkaloid that produces stimulation of the ganglia and central nervous system while in the human body. About 80 percent of the nicotine we inhale is converted in the liver to cotinine. This process makes cotinine an excellent urine marker for the detection of nicotine. Nicotine is a drug which virtually every member of the tobacco smoking society is exposed; whether through direct contact or second hand inhalation. This nicotine urine test detects cigarette smokers or users of other tobacco related products. In addition to tobacco, nicotine is commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, trans-dermal patches and nasal spray. Nicotine and Cotinine are rapidly eliminated by the kidney; the window of detection for Cotinine in urine at a cutoff level of 200ng/mL is expected to be up to 2-3 days after nicotine use. The One-Step Nicotine - Cotinine Test Device is a rapid urine screening test that can be performed as a home test or clinical with out the use of an instrument.
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