Tricyclic Antidepressants

 
 
 
What are Tricyclic Antidepressants? (TCA)
 
TCA (Tricyclic Antidepressants) are commonly used for the treatment of depressive disorders.  TCA overdoses can result in profound central nervous system depression, cardiotoxicity and anticholinergic effects.  TCA overdose is the most common cause of death from prescription drugs.  TCAs are taken orally or sometimes by injection.  TCAs are metabolized in the liver.  Both TCAs and their metabolites are excreted in urine mostly in the form of metabolites for up to ten days.  The test is intended for over-the-counter (OTC) use as the first step in a two step process to provide consumers with information concerning the presence or absence of the above stated drug in a urine sample.  Information regarding confirmatory testing - the second step in the process, along with the materials for shipping a portion of the urine specimen to the laboratory for confirmation testing of a preliminary positive result, the second step in the process, is provided.
 
- A class of drugs that are traditionally used to treat depression
 
- Relieve chronic nerve-related pain
 
- Reduce bed-wetting
 
- Manage obsessive compulsive behaviors
 
- Prevent migraines.
 
-  They increase levels of norepinephrine and serotonin by inhibiting their reuptake, and also block the actions of another neurotransmitter, acetylcholine
 
 
Brands of Tricyclics:
 
- Ascendin
- Norpramin
- Tofranil
- Sinequan
- Anafranil
- Surmontil
- Vivactil
- Elavil
- Silenor
- Pamelor
 
 
Possible Side Effects:
 
Dry mouth
- Blurred vision
- Sweating
- Dizziness or lightheadedness
- Drowsiness
- Restlessness
- Racing heartbeat
- Increased sweating
 
 
Detection Periods:
 
Urine = 5-10 Days​​​
 
Hair = Up to 90 Days